Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 May;42(5):367-368.
doi: 10.1016/j.it.2021.03.009. Epub 2021 Mar 30.

Tonsil organoids: peering down the throat of human immunity

Amy L Kenter  1 , Justin M Richner  2
Affiliations
Comment

Tonsil organoids: peering down the throat of human immunity

Amy L Kenter et al. Trends Immunol. 2021 May.

Abstract

Animal studies and explant cultures of human lymphoid tissues do not reliably model human vaccine responses. A remarkable strategy for reassociation of human tonsillar cells in ex vivo culture leads to organoid formation and provides an exciting new tool to probe human humoral immune responses to infection.

Keywords: germinal center; human immunology; organoid; tonsils; vaccine.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests No interests are declared.

Comment on

  • Modeling human adaptive immune responses with tonsil organoids.
    Wagar LE, Salahudeen A, Constantz CM, Wendel BS, Lyons MM, Mallajosyula V, Jatt LP, Adamska JZ, Blum LK, Gupta N, Jackson KJL, Yang F, Röltgen K, Roskin KM, Blaine KM, Meister KD, Ahmad IN, Cortese M, Dora EG, Tucker SN, Sperling AI, Jain A, Davies DH, Felgner PL, Hammer GB, Kim PS, Robinson WH, Boyd SD, Kuo CJ, Davis MM. Wagar LE, et al. Nat Med. 2021 Jan;27(1):125-135. doi: 10.1038/s41591-020-01145-0. Epub 2021 Jan 11. Nat Med. 2021. PMID: 33432170 Free PMC article.

Publication types

LinkOut - more resources