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Comment
. 2021 Apr 1;6(1):142.
doi: 10.1038/s41392-021-00556-w.

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

Sandeep Rana  1 , Amarnath Natarajan  2
Affiliations
Comment

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

Sandeep Rana et al. Signal Transduct Target Ther. .
No abstract available

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Figures

Fig. 1
Fig. 1
Small molecule BCL6 modulators and the binding mode of the BCL6 molecular glue. a Structure of BCL6 molecular glue BI-3802. b Structure of BCL6 inhibitor BI-3812. c Cyro-EM model of BCL6 filament with BI-3802 PDB code (6XMX). d Binding mode and key interaction made by BI-3802 (green) at the interface of BTBα (yellow), BTBβ (magenta), and BTBγ (orange) domains. e Structure of BCL6 PROTAC
See this image and copyright information in PMC

Comment on

  • Small-molecule-induced polymerization triggers degradation of BCL6.
    Słabicki M, Yoon H, Koeppel J, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Fröhling S, Nowak RP, Fischer ES, Ebert BL. Słabicki M, et al. Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1. Epub 2020 Nov 18. Nature. 2020. PMID: 33208943 Free PMC article.

References

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