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Case Reports
. 2021 Mar 11:22:101068.
doi: 10.1016/j.ajoc.2021.101068. eCollection 2021 Jun.

Unilateral benign yellow dot maculopathy

Amit V Mishra  1 , André S Pollmann  1 , Netan Choudhry  2   3 , Erin Demmings  1 , R Rishi Gupta  1
Affiliations
Case Reports

Unilateral benign yellow dot maculopathy

Amit V Mishra et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: To describe a unique case of unilateral benign yellow dot maculopathy.

Observations: A 25-year-man was evaluated after incidental finding of yellow dots in the right macula. The findings of examination and multimodal imaging were in keeping with a diagnosis of benign yellow dot maculopathy.

Conclusions and importance: Benign yellow dot maculopathy is a recently described entity with either a sporadic or dominant inheritance pattern. This is the first known report of the characteristic findings of this phenotype presenting unilaterally.

Keywords: Drusen; Maculopathy; Yellow dot.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Color fundus photo of the right eye (A) demonstrating fine discrete parafoveal yellow dots, which extend into the temporal macula. The left fundus is normal (B). 3.5× magnified image (C) of the yellow dots shows retinal vessels passing over the yellow dots. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2
Fig. 2
Blue fundus autofluorescence (Heidelberg Spectralis, Dossenheim, Germany) shows hyperautofluorescent dots in the posterior pole of the right eye (A) and a normal left fundus (B).
Fig. 3
Fig. 3
Spectal-domain optical coherence tomography (Heidelberg Engineering, Dossenheim, Germany) section through yellow dots (A). 3.5× magnified image (B) demonstrates diffuse hyperreflective spots and slight retinal pigment epithelium irregularity (arrowheads). Near-infrared reflectance imaging (C) shows hyper-reflective appearing dots in the macula. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 4
Fig. 4
Multifocal electroretinography results. Right affected eye trace array recordings (A) and 3-dimensional amplitude density plot (B) show slightly diminished peak signal intensity relative to the fellow eye but are within normal limits. Left trace array recordings (C) and 3-dimensional amplitude density plot (D) are within normal limits.
See this image and copyright information in PMC

References

    1. Michaelides M., Hunt D.M., Moore A.T. The genetics of inherited macular dystrophies. J Med Genet. 2003;40(9):641–650. - PMC - PubMed
    1. Dev Borman A., Rachitskaya A., Suzani M. Benign yellow dot maculopathy: a new macular phenotype. Ophthalmology. 2017;124(7):1004–1013. - PMC - PubMed
    1. Murro V., Mucciolo D.P., Giorgio D. Multimodal imaging of benign yellow dot maculopathy. Ophthalmic Genet. 2019;40(2):135–140. - PubMed
    1. Moisseiev E. Benign yellow dot maculopathy. Am J Ophthalmol Case Rep. 2018;10:13–15. - PMC - PubMed
    1. Hammer D.X., Liu Z., Cava J.A., Carroll J., Saeedi O. On the axial location of Gunn's dots. Am J Ophthalmol Case Rep. 2020;19:100757. - PMC - PubMed

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