Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun;61(6):1757-1763.
doi: 10.1111/trf.16394. Epub 2021 Apr 2.

Survey of group A plasma and low-titer group O whole blood use in trauma resuscitation at adult civilian level 1 trauma centers in the US

Mark H Yazer  1 , Philip C Spinella  2 , Vincent Anto  3 , Nancy M Dunbar  4
Affiliations

Survey of group A plasma and low-titer group O whole blood use in trauma resuscitation at adult civilian level 1 trauma centers in the US

Mark H Yazer et al. Transfusion. 2021 Jun.

Abstract

Background: Recently revisited products like low-titer group O whole blood (LTOWB) and novel applications of group A as a universal donor of plasma are being used for trauma resuscitation. A survey of American Level 1 trauma centers was performed to elucidate the extent to which these products are currently employed.

Methods: A survey was written that probed into the current use of blood products in trauma resuscitation with specific emphasis on LTOWB and group A plasma. A list of adult civilian Level 1 trauma centers in the continental USA was obtained from two public surgery and trauma focused websites. An email was then sent to each center's transfusion service medical director or laboratory manager providing them with a link to the online survey.

Results: Responses were received from 103/187 (55%) adult civilian Level 1 trauma centers. For the resuscitation of trauma patients, group A plasma was used at 94/103 (91%) centers, while LTOWB was used at 43/103 (42%) centers. There were 39/103 (38%) centers that used both products. At 62/94 (66%) of the centers that used group A plasma, there was no limit on the number of units that could be administered, while an unlimited number of LTOWB units could be used at 5/43 (12%) of the centers that used LTOWB. RhD-positive LTOWB could be transfused to RhD-negative or RhD-type unknown females of childbearing potential at 22/43 (51%) of centers.

Conclusion: The use of group A plasma and LTOWB in trauma is increasing at American Level 1 trauma centers.

Keywords: American; group A plasma; level 1; low titer group O whole blood; survey; transfusion; trauma.

PubMed Disclaimer

References

REFERENCES

    1. Myburgh JA, Mythen MG. Resuscitation fluids. N Engl J Med. 2013;369:2462-3.
    1. Bickell WH, Wall MJ Jr, Pepe PE, Martin RR, Ginger VF, Allen MK, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105-9.
    1. Harada MY, Ko A, Barmparas G, Smith EJT, Patel BK, Dhillon NK, et al. 10-year trend in crystalloid resuscitation: Reduced volume and lower mortality. Int J Surg. 2017;38:78-82.
    1. Ley EJ, Clond MA, Srour MK, Barnajian M, Mirocha J, Margulies DR, et al. Emergency department crystalloid resuscitation of 1.5 L or more is associated with increased mortality in elderly and nonelderly trauma patients. J Trauma. 2011;70:398-400.
    1. Woolley T, Thompson P, Kirkman E, Reed R, Ausset S, Beckett A, et al. Trauma hemostasis and oxygenation research network position paper on the role of hypotensive resuscitation as part of remote damage control resuscitation. J Trauma Acute Care Surg. 2018;84:S3-s13.

Substances

LinkOut - more resources