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. 2021 Jan-Mar;57(1):33-36.
doi: 10.4415/ANN_21_01_05.

First evidence of blaNDM-1 and blaOXA-23 carbapenemase genes in human body lice infesting a second-hand T-shirt in a street market in Italy

Fabiola Mancini  1 , Laura Villa  1 , Michela Menegon  1 , Marco Di Luca  1 , Luciano Toma  1 , Claudio De Liberato  2 , Adele Magliano  2 , Federico Romiti  2 , Alessandra Carattoli  3 , Alessandra Ciervo  1
Affiliations

First evidence of blaNDM-1 and blaOXA-23 carbapenemase genes in human body lice infesting a second-hand T-shirt in a street market in Italy

Fabiola Mancini et al. Ann Ist Super Sanita. 2021 Jan-Mar.

Abstract

Background: The spread of carbapenems resistance is a public health concern. The main group of carbapenemases encoding the β-lactamases activity (bla genes) is the Metallo-β-lactamases (MBLs).

Methods: The presence of carbapenemase blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, blaOXA-58-like, and blaNDM-1 genes was screened by real time PCR in 26 Pediculus humanus insects identified from second-hand clothes in a local market in Central Italy. Bacteria diversity was also characterized through shotgun metagenomic amplification for a deep sequencing of the host-associated bacterial microbiomes.

Results: The blaOXA-23 and blaNDM-1 carbapenemases genes were found and metagenomic analysis showed a great presence of Acinetobacter species.

Conclusions: These results suggest a new potential transmission path for carbapenemase gene spread through bacteria ingested by insects infesting humans.

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