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Review
. 2021 Aug;45(8):1941-1946.
doi: 10.1007/s00264-021-04977-8. Epub 2021 Apr 2.

Immunologic reactions to bone and articular implants

Cristian Paul Dan  1 , Simona Irina Dan  2 , Adrian Alexandru Dorin Silaşi  3 , Gheorghe Tomoaia  4   5
Affiliations
Review

Immunologic reactions to bone and articular implants

Cristian Paul Dan et al. Int Orthop. 2021 Aug.

Abstract

Background: In recent years the number on implantable devices that have been used in orthopedic surgeries has increased exponentially. As the number of people with orthopedic implants has grown, implant failure has become an increasingly important public health issue. While a significant percent of joint implants fails at between 15 and 20 years some authors suggest that one of the main causes is the interaction between the immune system of the host and the material of the implant METHODS: The search engines used for research comprised of PubMed, Google Scholar and Cochrane Library.

Results: This review aims to summarize relevant and recent data on the immune reactions that are taking place at the juxtaposition between the implant and the patient's tissue, the time frame in which these immune reactions take place and some of the factors that can influence this reaction. The immune reactions can be divided into: hyperacute immune reactions (anaphylactic shock), acute reactions, the transition between the acute phase and the chronic phase and last but not least chronic immune reactions to such implants.

Conclusion: The research being done with regard to implant-related immunology strives to help in solving the problem of long-term implant failure.

Keywords: Acute immune reaction; Aseptic loosening; Chronic immune reaction; Immunology; Leukocyte; Macrophage; Orthopedic implants; Osteoimmunology; Polymorphonuclear.

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