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Review
. 2022 Apr;69(2):848-861.
doi: 10.1002/bab.2156. Epub 2021 Apr 14.

Advances in biochemistry and the biotechnological production of taxifolin and its derivatives

Nguyen Huy Thuan  1 , Anil Shrestha  2 , Nguyen Thanh Trung  1 , Vinay Bharadwaj Tatipamula  1 , Duong Van Cuong  3 , Nguyen Xuan Canh  4 , Nguyen Van Giang  4 , Tae-Su Kim  5 , Jae Kyung Sohng  5 , Dipesh Dhakal  6
Affiliations
Review

Advances in biochemistry and the biotechnological production of taxifolin and its derivatives

Nguyen Huy Thuan et al. Biotechnol Appl Biochem. 2022 Apr.

Abstract

Taxifolin (dihydroquercetin) and its derivatives are medicinally important flavanonols with a wide distribution in plants. These compounds have been isolated from various plants, such as milk thistle, onions, french maritime, and tamarind. In general, they are commercially generated in semisynthetic forms. Taxifolin and related compounds are biosynthesized via the phenylpropanoid pathway, and most of the biosynthetic steps have been functionally characterized. The knowledge gained through the detailed investigation of their biosynthesis has provided the foundation for the reconstruction of biosynthetic pathways. Plant- and microbial-based platforms are utilized for the expression of such pathways for generating taxifolin-related compounds, either by whole-cell biotransformation or through reconfiguration of the genetic circuits. In this review, we summarize recent advances in the biotechnological production of taxifolin and its derivatives.

Keywords: astilbin; chemical; metabolism; pharmaceutical activity; taxifolin.

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References

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