K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2^VHL

Charlene M Magtoto¹, Rebecca Feltham²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
² The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: feltham.r@wehi.edu.au.

PMID: 33798411
DOI: 10.1016/j.molcel.2021.02.030

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K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2^VHL

Charlene M Magtoto et al. Mol Cell. 2021.

Free article

. 2021 Apr 1;81(7):1363-1365.

doi: 10.1016/j.molcel.2021.02.030.

Authors

Charlene M Magtoto¹, Rebecca Feltham²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
² The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: feltham.r@wehi.edu.au.

PMID: 33798411
DOI: 10.1016/j.molcel.2021.02.030

Abstract

In this issue of Molecular Cell, Kaiho-Soma et al. (2021) demonstrate that the HECT-type E3 ubiquitin ligase TRIP12 cooperates with CRL complexes to promote PROTAC-induced degradation of neo-substrates by generating K29/K48-branched ubiquitin chains.

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TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
Kaiho-Soma A, Akizuki Y, Igarashi K, Endo A, Shoda T, Kawase Y, Demizu Y, Naito M, Saeki Y, Tanaka K, Ohtake F. Kaiho-Soma A, et al. Mol Cell. 2021 Apr 1;81(7):1411-1424.e7. doi: 10.1016/j.molcel.2021.01.023. Epub 2021 Feb 9. Mol Cell. 2021. PMID: 33567268

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K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2^VHL

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K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2^VHL

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