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Comment
. 2021 Apr 1;81(7):1370-1371.
doi: 10.1016/j.molcel.2021.03.005.

NINJ1, rupturing swollen membranes for cataclysmic cell lysis

Yupeng Wang  1 , Feng Shao  2
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NINJ1, rupturing swollen membranes for cataclysmic cell lysis

Yupeng Wang et al. Mol Cell. .
Free article

Abstract

Using a forward-genetic screening of macrophages from randomly mutagenized mice, Kayagaki et al. (2021) identify NINJ1 that mediates plasma membrane rupture following various types of programmed cell death, an event previously thought to be passive.

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  • NINJ1 mediates plasma membrane rupture during lytic cell death.
    Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. Kayagaki N, et al. Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20. Nature. 2021. PMID: 33472215

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