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Comment
. 2021 Apr 1;28(4):592-594.
doi: 10.1016/j.stem.2021.03.007.

New dog, old tricks: Developmental programs resurface in inflammation

Daniel Rosenblum  1 , Shruti Naik  2
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Free article
Comment

New dog, old tricks: Developmental programs resurface in inflammation

Daniel Rosenblum et al. Cell Stem Cell. .
Free article

Abstract

Cellular cartography of human tissues has provided unprecedented insight into health and disease. In a recent issue of Science, Reynolds et al. (2021) use single-cell transcriptomics to define cell states and gene programs in human skin and uncover fetal programs in dermatological diseases that may fuel inflammatory pathology.

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  • Developmental cell programs are co-opted in inflammatory skin disease.
    Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N, Olabi B, Dubois A, Dixon D, Green K, Maunder D, Engelbert J, Efremova M, Polański K, Jardine L, Jones C, Ness T, Horsfall D, McGrath J, Carey C, Popescu DM, Webb S, Wang XN, Sayer B, Park JE, Negri VA, Belokhvostova D, Lynch MD, McDonald D, Filby A, Hagai T, Meyer KB, Husain A, Coxhead J, Vento-Tormo R, Behjati S, Lisgo S, Villani AC, Bacardit J, Jones PH, O'Toole EA, Ogg GS, Rajan N, Reynolds NJ, Teichmann SA, Watt FM, Haniffa M. Reynolds G, et al. Science. 2021 Jan 22;371(6527):eaba6500. doi: 10.1126/science.aba6500. Science. 2021. PMID: 33479125 Free PMC article.

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