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Comment
. 2021 Apr 1;29(4):305-307.
doi: 10.1016/j.str.2021.03.009.

Src-mediated phosphorylation of RIAM promotes integrin activation

Frédéric Lagarrigue  1 , Alexandre R Gingras  2
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Comment

Src-mediated phosphorylation of RIAM promotes integrin activation

Frédéric Lagarrigue et al. Structure. .
Free article

Abstract

In this issue of Structure, Cho et al. (2020) identified an intermolecular interaction between two RIAM pleckstrin homology (PH) domains that masks the phosphoinositide-binding site, and that phosphorylation by Src unmasks the PH domain. This provides an explanation of how RIAM plasma membrane translocation is regulated to promote integrin activation.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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