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Review
. 2021 Apr 1;184(7):1661-1670.
doi: 10.1016/j.cell.2021.02.055.

The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment

Henry Rodriguez  1 , Jean Claude Zenklusen  2 , Louis M Staudt  2 , James H Doroshow  3 , Douglas R Lowy  4
Affiliations
Review

The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment

Henry Rodriguez et al. Cell. .

Abstract

When it comes to precision oncology, proteogenomics may provide better prospects to the clinical characterization of tumors, help make a more accurate diagnosis of cancer, and improve treatment for patients with cancer. This perspective describes the significant contributions of The Cancer Genome Atlas and the Clinical Proteomic Tumor Analysis Consortium to precision oncology and makes the case that proteogenomics needs to be fully integrated into clinical trials and patient care in order for precision oncology to deliver the right cancer treatment to the right patient at the right dose and at the right time.

Keywords: cancer diagnosis; cancer treatment; clinical trial; collaboration; data sharing; genomics; molecular medicine; open access; precision medicine; precision oncology; proteogenomics; proteomics; targeted therapy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1:
Figure 1:
In this figurative piece, the role of proteogenomics in precision oncology is illustrated by a cancer patient looking out into the horizon. His horizon is framed by DNA and RNA hills (genomics) and protein clouds (proteomics) which together represent the keys to overcoming scientific mountains. The strong ray of sunlight embodies the current contributions of genomics to oncology, lighting the path to the next step in the journey, multi-omics molecular characterization of patient tumors. The patient looks forward to a brighter horizon, one where genomic and proteomic molecular diagnoses are combined into clinical trials and patient care, one where patients and families are gifted with hope.
See this image and copyright information in PMC

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