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. 2021 Jul;225(1):101-103.
doi: 10.1016/j.ajog.2021.03.031. Epub 2021 Mar 31.

Anti-severe acute respiratory syndrome coronavirus 2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination

Jeannie C Kelly  1 , Ebony B Carter  2 , Nandini Raghuraman  2 , Lila S Nolan  3 , Qingqing Gong  3 , Angela N Lewis  3 , Misty Good  3
Affiliations

Anti-severe acute respiratory syndrome coronavirus 2 antibodies induced in breast milk after Pfizer-BioNTech/BNT162b2 vaccination

Jeannie C Kelly et al. Am J Obstet Gynecol. 2021 Jul.
No abstract available

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Figures

Figure
Figure
Breast milk levels of anti–SARS-CoV-2 antibodies after Pfizer-BioNTech/BNT162b2 vaccination A total of 5 lactating women who received 2 doses of the Pfizer-BioNTech BNT162b2 vaccine were included in the analysis. A, Self-reported clinical data of the study subjects are shown, with Subject 2 identifying as immunocompromised; B, Prevaccine baseline milk samples were analyzed for SARS-CoV-2 RNA using the N1 target compared with RNAse P, with undetectable viral RNA defined as Ct>40. Antispike protein (C) IgG and (D) IgA antibody levels in human milk were analyzed at serial time points following the first and second vaccine doses. Delipidated human milk samples were diluted at a 1:1 ratio with sample diluent and tested in duplicate for IgG and IgA against SARS-CoV-2 full-length spike protein using ELISA Kits from Cell Signaling Technology (Catalog #20154C for IgG and Catalog #58873C for IgA). Antibody signal detections were analyzed by spectrophotometric absorbance at 450 nm. Gray vertical lines represent the timing of the administration of the second dose. Of note, the first sample from Subject 1 was obtained 17 days after the first vaccine. Data are displayed as mean±SEM and were analyzed using the Mann-Whitney U test. The single asterisk represents P<.05; the double asterisk represents P<.01. Ct, cycle threshold; ELISA, enzyme-linked immunosorbent assay; Ig, immunoglobulin; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SEM, standard error of the mean. Kelly. Severe acute respiratory syndrome coronavirus 2 antibodies in breast milk after vaccination. Am J Obstet Gynecol 2021.
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References

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