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Review
. 2021 Sep;26(9):2090-2094.
doi: 10.1016/j.drudis.2021.03.023. Epub 2021 Mar 31.

Innovation in infectious disease therapies from immunology

Deborah A O'Neil  1
Affiliations
Review

Innovation in infectious disease therapies from immunology

Deborah A O'Neil. Drug Discov Today. 2021 Sep.

Abstract

Antimicrobial therapies developed from immunology, specifically the primary function of the immune system in host defence against microbial pathogens, could offer some of the step-change strategies in drug design and development urgently required to generate much needed, truly novel interventions in infectious disease. The immune system is an as yet underexploited resource of novel molecules and the blueprints for new approaches to combating infection with non-antibiotic, directly antimicrobial strategies.

Keywords: Aminothiol; Antimicrobial peptide; Antimicrobial resistance; Antimicrobial therapy; Immunotherapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: D.A.O’N. is an employee, director, and shareholder of NovaBiotics and is a named inventor on all NovaBiotics patents protecting the peptide and thiol anti-infective therapies referenced in this manuscript.

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