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. 2021 Jun:25:171-180.
doi: 10.1016/j.jgar.2021.03.017. Epub 2021 Mar 31.

Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology

Maurine D'Agostino  1 , Nicolas Tesse  2 , Rose Anne Lavergne  3 , Patrice Le Pape  3 , Jean Philippe Bouchara  4 , Jean Pol Frippiat  5 , Marie Machouart  6 , Anne Debourgogne  6
Affiliations
Free article

Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology

Maurine D'Agostino et al. J Glob Antimicrob Resist. 2021 Jun.
Free article

Abstract

Objectives: Today, the increase of invasive fungal infections and the emergence of resistant strains are observed in medical practice. New antifungals are expected, and the plant world offers a panel of potentially active molecules. CIN-102 is a mixture of seven different compounds of plant origin developed from the formulation of cinnamon essential oil.

Methods: The in vitro activity of CIN-102 was characterised against Aspergillus spp., Fusarium spp. and Scedosporium spp. by studying the minimum inhibitory concentration (MIC), inoculum effect, germination inhibition, fungal growth, post-antifungal effect (PAFE) and synergy.

Results: MICs determined for the three genera followed a unimodal distribution and their mean values ranged from 62-250 μg/mL. CIN-102 demonstrated an inoculum effect similar to voriconazole and amphotericin B, 100% inhibition of spore germination and a PAFE.

Conclusion: CIN-102 has significant activity against filamentous fungi involved in human pathologies and should be further explored as a potential new treatment. Other studies regarding its mechanisms of action as well as animal investigations are awaited.

Keywords: Antifungal; Aspergillus; Fungi; Fusarium; Scedosporium.

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