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Review
. 2021 Mar 11;22(6):2829.
doi: 10.3390/ijms22062829.

Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration

Joaquín Guerra Gómez  1 , Jesús Devesa  2
Affiliations
Review

Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration

Joaquín Guerra Gómez et al. Int J Mol Sci. .

Abstract

Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial effects in humans presented and substantiated in the main text, although they should not exaggerate the main conclusions.

Keywords: GH deficiency; IGF-I; central auditory processing; growth hormone; hearing impairment; hereditary hearing loss.

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Conflict of interest statement

The authors declare no conflict of interest.

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