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Review
. 2021 Mar 11;10(6):1175.
doi: 10.3390/jcm10061175.

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Emaad M Abdel-Rahman  1 , Faruk Turgut  2 , Jitendra K Gautam  1 , Samir C Gautam  3
Affiliations
Review

Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

Emaad M Abdel-Rahman et al. J Clin Med. .

Abstract

Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid impairment of kidney function. The incidence of AKI and its severe form AKI requiring dialysis (AKI-D) has been increasing over the years. AKI etiology may be multifactorial and is substantially associated with increased morbidity and mortality. The outcome of AKI-D can vary from partial or complete recovery to transitioning to chronic kidney disease, end stage kidney disease, or even death. Predicting outcomes of patients with AKI is crucial as it may allow clinicians to guide policy regarding adequate management of this problem and offer the best long-term options to their patients in advance. In this manuscript, we will review the current evidence regarding the determinants of AKI outcomes, focusing on AKI-D.

Keywords: acute kidney injury; biomarkers; mortality; recovery.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. 2012;2:1–138.
    1. Chawla L.S., Bellomo R., Bihorac A., Goldstein S.L., Siew E.D., Bagshaw S.M., Bittleman D., Cruz D., Endre Z., Fitzgerald R.L., et al. Acute kidney disease and renal recovery: Consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nat. Rev. Nephrol. 2017;13:241–257. doi: 10.1038/nrneph.2017.2. - DOI - PubMed
    1. Cerdá J., Liu K.D., Cruz D.N., Jaber B.L., Koyner J.L., Heung M., Okusa M.D., Faubel S. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin. J. Am. Soc. Nephrol. 2015;10:1859–1867. doi: 10.2215/CJN.01170215. - DOI - PMC - PubMed
    1. Hoste E.A., Bagshaw S.M., Bellomo R., Cely C.M., Colman R., Cruz D.N., Edipidis K., Forni L.G., Gomersall C.D., Govil D., et al. Epidemiology of acute kidney injury in critically ill patients: The multinational AKI-EPI study. Intensive Care Med. 2015;41:1411–1423. doi: 10.1007/s00134-015-3934-7. - DOI - PubMed
    1. Uchino S., Kellum J.A., Bellomo R., Doig G.S., Morimatsu H., Morgera S., Schetz M., Tan I., Bouman C., Macedo E., et al. Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA. 2005;294:813–818. doi: 10.1001/jama.294.7.813. - DOI - PubMed

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