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. 1988 Apr;8(4):1845-8.
doi: 10.1128/mcb.8.4.1845-1848.1988.

Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay

T D Halazonetis  1 , C Daugherty, P Leder
Affiliations

Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay

T D Halazonetis et al. Mol Cell Biol. 1988 Apr.

Abstract

The rat embryo fibroblast focus assay is used to evaluate the transforming potential of several oncogenes. The sensitivity of this assay increased fivefold when retinoic acid was added to tissue culture media. Retinoic acid probably acts by selectively inhibiting the proliferation of nontransformed cells.

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