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. 2021 Mar 21;13(3):1010.
doi: 10.3390/nu13031010.

Prevalence of Anemia, Iron-Deficiency Anemia, and Associated Factors among Children Aged 1-5 Years in the Rural, Malaria-Endemic Setting of Popokabaka, Democratic Republic of Congo: A Cross-Sectional Study

Branly Kilola Mbunga  1 , Mala Ali Mapatano  1 , Tor A Strand  2 , Elin Lovise F Gjengedal  3 , Pierre Zalagile Akilimali  1 , Ingunn Marie S Engebretsen  2
Affiliations

Prevalence of Anemia, Iron-Deficiency Anemia, and Associated Factors among Children Aged 1-5 Years in the Rural, Malaria-Endemic Setting of Popokabaka, Democratic Republic of Congo: A Cross-Sectional Study

Branly Kilola Mbunga et al. Nutrients. .

Abstract

Iron deficiency (ID), the leading cause of anemia and the most common nutritional deficiency globally, is not well reported among children in malaria-endemic settings, and little is known about its contribution to anemia in these settings. We aimed to assess the prevalence of anemia, the role of ID using multiple parameters, and the factors associated with anemia in a malaria-endemic rural area. We conducted a community-based cross-sectional study of 432 children aged 1-5 years from the Popokabaka Health Zone, Democratic Republic of Congo. Sociodemographic characteristics, medical history, anthropometric parameters, and biochemical parameters were considered. Hemoglobin and malaria prevalence were assessed using rapid finger-prick capillary blood testing in the field. Venous blood samples were analyzed for serum ferritin, serum iron, total iron-binding capacity, and C-reactive protein (CRP) in a laboratory. Anemia was found in 294 out of 432 (68%) patients. Malaria was found in 375 out of 432 (87%), and ID in 1.8% according to diagnosis by adjusted ferritin only and in 12.9% according to transferrin saturation. ID indicators were not significantly correlated with low hemoglobin levels. Malaria, fever, and CRP > 5 mg/L were major factors associated with anemia in Popokabaka. Anemia control should focus on treating inflammatory conditions and infectious diseases among children in such settings.

Keywords: Popokabaka; anemia; children; iron deficiency; malaria.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Kassebaum N.J., Jasrasaria R., Naghavi M., Wulf S.K., Johns N., Lozano R., Regan M., Weatherall D., Chou D.P., Eisele T.P., et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123:615–624. doi: 10.1182/blood-2013-06-508325. - DOI - PMC - PubMed
    1. WHO The Global Health Observatory Prevalence of Anaemia in Children under 5 Years (%) [(accessed on 29 August 2020)];2017 Available online: https://www.who.int/data/gho/data/indicators/indicator-details/GHO/preva...
    1. MinisterePlan_DRC Congo Democratic Republic-Democratic Health Survey (DHS) [(accessed on 23 November 2020)];2014 Available online: https://dhsprogram.com/pubs/pdf/FR300/FR300.pdf.
    1. National Institute of Statistics Multiple Indicators Clustered Survey 2017 2018-Congo Democratic. Survey Finding Report. [(accessed on 23 November 2020)]; Available online: https://www.unicef.org/drcongo/en/reports/mics-palu-2018.
    1. Petry N., Olofin I., Hurrell R.F., Boy E., Wirth J.P., Moursi M., Angel M.D., Rohner F. The Proportion of Anemia Associated with Iron Deficiency in Low, Medium, and High Human Development Index Countries: A Systematic Analysis of National Surveys. Nutrients. 2016;8:693. doi: 10.3390/nu8110693. - DOI - PMC - PubMed