Novel Strategies for Treating Castration-Resistant Prostate Cancer
- PMID: 33801751
- PMCID: PMC8066514
- DOI: 10.3390/biomedicines9040339
Novel Strategies for Treating Castration-Resistant Prostate Cancer
Abstract
The development of castration resistance is an inevitable pathway for the vast majority of patients with advanced prostate cancer. Recently, there have been significant breakthroughs in the understanding and management options of castration-resistant prostate cancer. Three novel hormonal agents showed survival benefits in non-metastatic patients. As for metastatic disease, there was an even wider range of management options being investigated. This review summarized advances in the management of castration-resistant prostate cancer (CRPC) including emerging data on novel imaging techniques and treatment strategies.
Keywords: androgen deprivation therapy; castration resistance; prostate cancer.
Conflict of interest statement
The authors declare no conflict of interest.
References
-
- Ferlay J., Ervik M., Lam F., Colombet M., Mery L., Piñeros M., Znaor A., Soerjomataram I., Bray F. Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer; Lyon, France: 2018.
-
- Hörnberg E., Ylitalo E.B., Crnalic S., Antti H., Stattin P., Widmark A., Bergh A., Wikström P. Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival. PLoS ONE. 2011;6:e19059. doi: 10.1371/journal.pone.0019059. - DOI - PMC - PubMed
-
- Cornford P., van den Bergh R.C., Briers E., Van den Broeck T., Cumberbatch M.G., De Santis M., Fanti S., Fossati N., Gandaglia G., Gillessen S. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II—2020 Update: Treatment of Relapsing and Metastat-ic Prostate Cancer. Eur. Urol. 2020 doi: 10.1016/j.eururo.2020.09.046. - DOI - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials