Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant's: A Systematic Review

doi:10.3390/jcm10061152

Review

. 2021 Mar 10;10(6):1152.

doi: 10.3390/jcm10061152.

Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant's: A Systematic Review

Affiliations

¹ Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia.
² Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
³ Department of Oral and Maxillo Facial Sciences, Univerisity of Rome "La Sapienza", 00161 Rome, Italy.
⁴ Private Dental Practice, Kochi 682019, India.
⁵ Private Dental Practice, Delhi 110075, India.
⁶ Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India.
⁷ Department of Dentistry, Bharathirajaa Hospital, and Research Institute, Chennai 600017, India.
⁸ Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

PMID: 33801820
PMCID: PMC7999954
DOI: 10.3390/jcm10061152

Review

Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant's: A Systematic Review

Shilpa Bhandi et al. J Clin Med. 2021.

. 2021 Mar 10;10(6):1152.

doi: 10.3390/jcm10061152.

Authors

Affiliations

¹ Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia.
² Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
³ Department of Oral and Maxillo Facial Sciences, Univerisity of Rome "La Sapienza", 00161 Rome, Italy.
⁴ Private Dental Practice, Kochi 682019, India.
⁵ Private Dental Practice, Delhi 110075, India.
⁶ Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India.
⁷ Department of Dentistry, Bharathirajaa Hospital, and Research Institute, Chennai 600017, India.
⁸ Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

PMID: 33801820
PMCID: PMC7999954
DOI: 10.3390/jcm10061152

Abstract

Removal of microbes is imperative during endodontic therapy. Due to their antimicrobial property, silver nanoparticles have been used for endodontic irrigation of the root canals. The objective of the present study was to provide a qualitative analysis of the published literature assessing silver nanoparticles as root canal irrigants. A search of PubMed, SCOPUS, Web of Science, and Embase databases was done without any time restriction. Articles published in English were included. Data were extracted and the risk of bias was assessed. Of the 154 studies identified, after screening according to the inclusion criteria, five in vitro studies were included. The results indicate that silver nanoparticles have an anti-microbial effect to varying degrees depending on certain factors. Within the limitations of the present studies that have a moderate to low risk of bias, an antimicrobial effect of silver nanoparticles is observed. Silver nanoparticles have the potential to be used as endodontic irrigants, although their efficacy depends on particle size and the duration of contact which require further investigation.

Keywords: antimicrobials; endodontics; irrigant; root canal; silver nanoparticles.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
PRISMA Flowchart depicting the workflow of the systematic review.

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References

1. Lin L.M., Skribner J.E., Gaengler P. Factors associated with endodontic treatment failures. J. Endod. 1992;18:625–627. doi: 10.1016/S0099-2399(06)81335-X. - DOI - PubMed
1. Tabassum S., Khan F.R. Failure of endodontic treatment: The usual suspects. Eur. J. Dent. 2016;10:144–147. doi: 10.4103/1305-7456.175682. - DOI - PMC - PubMed
1. Nair P.N.R., Henry S., Cano V., Vera J. Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after “one-visit” endodontic treatment. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2005;99:231–252. doi: 10.1016/j.tripleo.2004.10.005. - DOI - PubMed
1. Palma P.J., Messias A., Cerqueira A.R., Tavares L.D., Caramelo F., Roseiro L., Santos J.M. Cyclic fatigue resistance of three rotary file systems in a dynamic model after immersion in sodium hypochlorite. Odontology. 2019;107:324–332. doi: 10.1007/s10266-018-0401-2. - DOI - PubMed
1. Tzanetakis G.N., Azcarate-Peril M.A., Zachaki S., Panopoulos P., Kontakiotis E.G., Madianos P.N., Divaris K. Comparison of Bacterial Community Composition of Primary and Persistent Endodontic Infections Using Pyrosequencing. J. Endod. 2015;41:1226–1233. doi: 10.1016/j.joen.2015.03.010. - DOI - PMC - PubMed

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[1] Lin L.M., Skribner J.E., Gaengler P. Factors associated with endodontic treatment failures. J. Endod. 1992;18:625–627. doi: 10.1016/S0099-2399(06)81335-X. - DOI - PubMed

[2] Lin L.M., Skribner J.E., Gaengler P. Factors associated with endodontic treatment failures. J. Endod. 1992;18:625–627. doi: 10.1016/S0099-2399(06)81335-X. - DOI - PubMed

[3] Tabassum S., Khan F.R. Failure of endodontic treatment: The usual suspects. Eur. J. Dent. 2016;10:144–147. doi: 10.4103/1305-7456.175682. - DOI - PMC - PubMed

[4] Tabassum S., Khan F.R. Failure of endodontic treatment: The usual suspects. Eur. J. Dent. 2016;10:144–147. doi: 10.4103/1305-7456.175682. - DOI - PMC - PubMed

[5] Nair P.N.R., Henry S., Cano V., Vera J. Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after “one-visit” endodontic treatment. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2005;99:231–252. doi: 10.1016/j.tripleo.2004.10.005. - DOI - PubMed

[6] Nair P.N.R., Henry S., Cano V., Vera J. Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after “one-visit” endodontic treatment. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2005;99:231–252. doi: 10.1016/j.tripleo.2004.10.005. - DOI - PubMed

[7] Palma P.J., Messias A., Cerqueira A.R., Tavares L.D., Caramelo F., Roseiro L., Santos J.M. Cyclic fatigue resistance of three rotary file systems in a dynamic model after immersion in sodium hypochlorite. Odontology. 2019;107:324–332. doi: 10.1007/s10266-018-0401-2. - DOI - PubMed

[8] Palma P.J., Messias A., Cerqueira A.R., Tavares L.D., Caramelo F., Roseiro L., Santos J.M. Cyclic fatigue resistance of three rotary file systems in a dynamic model after immersion in sodium hypochlorite. Odontology. 2019;107:324–332. doi: 10.1007/s10266-018-0401-2. - DOI - PubMed

[9] Tzanetakis G.N., Azcarate-Peril M.A., Zachaki S., Panopoulos P., Kontakiotis E.G., Madianos P.N., Divaris K. Comparison of Bacterial Community Composition of Primary and Persistent Endodontic Infections Using Pyrosequencing. J. Endod. 2015;41:1226–1233. doi: 10.1016/j.joen.2015.03.010. - DOI - PMC - PubMed

[10] Tzanetakis G.N., Azcarate-Peril M.A., Zachaki S., Panopoulos P., Kontakiotis E.G., Madianos P.N., Divaris K. Comparison of Bacterial Community Composition of Primary and Persistent Endodontic Infections Using Pyrosequencing. J. Endod. 2015;41:1226–1233. doi: 10.1016/j.joen.2015.03.010. - DOI - PMC - PubMed

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Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant's: A Systematic Review

Affiliations

Antimicrobial Efficacy of Silver Nanoparticles as Root Canal Irrigant's: A Systematic Review

Authors

Affiliations

Abstract

Conflict of interest statement

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Cited by

References

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