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Review
. 2021 Mar 3;13(3):830.
doi: 10.3390/nu13030830.

Role of Vitamin D in the Metabolic Syndrome

Lucía Melguizo-Rodríguez  1   2 , Víctor J Costela-Ruiz  1   2 , Enrique García-Recio  1   2 , Elvira De Luna-Bertos  1   2 , Concepción Ruiz  1   2   3 , Rebeca Illescas-Montes  1   2
Affiliations
Review

Role of Vitamin D in the Metabolic Syndrome

Lucía Melguizo-Rodríguez et al. Nutrients. .

Abstract

The prevalence of hypovitaminosis D has risen in developed countries over the past few years in association with lifestyle changes and an increase in unhealthy habits. Vitamin D deficiency has been implicated in various diseases, including metabolic syndrome (MetS), which is clinically defined by a set of metabolic and vascular disorders. The objective of this study was to review scientific evidence on the relationship between MetS and vitamin D deficiency to support the development of prevention strategies and health education programs. An inverse relationship has been reported between plasma vitamin D concentrations and the features that define MetS, i.e., elevated serum concentrations of glucose, total cholesterol, low-density lipoproteins, triglycerides, glycosylated hemoglobin, and a high body mass index. Numerous studies have described the benefits of vitamin D supplementation to improve outcomes in individuals with MetS. Interventions to maintain optimal vitamin D concentrations are proposed as a preventive strategy against MetS.

Keywords: cardiovascular risk; diabetes mellitus; insulin resistance; metabolic syndrome; obesity; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Vitamin D synthesis pathways.
See this image and copyright information in PMC

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