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. 2021 Mar 9;10(3):278.
doi: 10.3390/antibiotics10030278.

Bacterial Pathogens and Evaluation of a Cut-Off for Defining Early and Late Neonatal Infection

Pavla Kucova  1 , Lumir Kantor  2 , Katerina Fiserova  1 , Jakub Lasak  2 , Magdalena Röderova  1 , Milan Kolar  1
Affiliations

Bacterial Pathogens and Evaluation of a Cut-Off for Defining Early and Late Neonatal Infection

Pavla Kucova et al. Antibiotics (Basel). .

Abstract

Bacterial infections are an important cause of mortality and morbidity in newborns. The main risk factors include low birth weight and prematurity. The study identified the most common bacterial pathogens causing neonatal infections including their resistance to antibiotics in the Neonatal Department of the University Hospital Olomouc. Additionally, the cut-off for distinguishing early- from late-onset neonatal infections was assessed. The results of this study show that a cut-off value of 72 h after birth is more suitable. Only in case of early-onset infections arising within 72 h of birth, initial antibiotic therapy based on gentamicin with ampicillin or amoxicillin/clavulanic acid may be recommended. It has been established that with the 72-h cut-off, late-onset infections caused by bacteria more resistant to antibiotics may be detected more frequently, a finding that is absolutely crucial for antibiotic treatment strategy.

Keywords: antibiotic therapy; bacteria; infection; newborn.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Proportional representation of early- and late-onset infections with regard to both cut-offs (72-h and 7-day) shown for Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, coagulase-negative staphylococci, Pseudomonas aeruginosa, and Candida albicans.
Figure 2
Figure 2
Pulsed-field gel electrophoresis (PFGE) of 3 CTX-M-15-positive Klebsiella pneumonia strains.
Figure 3
Figure 3
PFGE of 2 CTX-M-15-positive Escherichia coli strains.
See this image and copyright information in PMC

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