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Review
. 2021 Mar 9;10(5):1146.
doi: 10.3390/jcm10051146.

Ischemic Stroke and Heart Failure: Facts and Numbers. An Update

Anush Barkhudaryan  1   2 , Wolfram Doehner  3   4   5 , Nadja Scherbakov  3   4   5
Affiliations
Review

Ischemic Stroke and Heart Failure: Facts and Numbers. An Update

Anush Barkhudaryan et al. J Clin Med. .

Abstract

Heart failure (HF) is a severe clinical syndrome accompanied by a number of comorbidities. Ischemic stroke occurs frequently in patients with HF as a complication of the disease. In the present review, we aimed to summarize the current state of research on the role of cardio-cerebral interactions in the prevalence, etiology, and prognosis of both diseases. The main pathophysiological mechanisms underlying the development of stroke in HF and vice versa are discussed. In addition, we reviewed the results of recent clinical trials investigating the prevalence and prevention of stroke in patients with HF.

Keywords: HFpEF; HFrEF; cardio–cerebral interactions; ischemic stroke; risk factor; stroke prevention.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
The comorbidities and risk factors in ischemic stroke and heart failure.
See this image and copyright information in PMC

References

    1. Sennfält S., Pihlsgård M., Petersson J., Norrving B., Ullberg T. Long-term outcome after ischemic stroke in relation to comorbidity—An observational study from the Swedish Stroke Register (Riksstroke) Eur. Stroke J. 2020;5:36–46. doi: 10.1177/2396987319883154. - DOI - PMC - PubMed
    1. Siedler G., Sommer K., Macha K., Marsch A., Breuer L., Stoll S., Engelhorn T., Dörfler A., Arnold M., Schwab S., et al. Heart Failure in Ischemic Stroke: Relevance for Acute Care and Outcome. Stroke. 2019;50:3051–3056. doi: 10.1161/STROKEAHA.119.026139. - DOI - PubMed
    1. Ponikowski P., Voors A.A., Anker S.D., Bueno H., Cleland J.G., Coats A.J., Falk V., González-Juanatey J.R., Harjola V.P., Jankowska E.A., et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur. J. Heart Fail. 2016;18:891–975. - PubMed
    1. Branca L., Sbolli M., Metra M., Fudim M. Heart failure with mid-range ejection fraction: Pro and cons of the new classification of Heart Failure by European Society of Cardiology guidelines. ESC Heart Fail. 2020;7:381–399. doi: 10.1002/ehf2.12586. - DOI - PMC - PubMed
    1. Krishnamurthi R.V., Ikeda T., Feigin V.L. Global, Regional and Country-Specific Burden of Ischaemic Stroke, Intracerebral Haemorrhage and Subarachnoid Haemorrhage: A Systematic Analysis of the Global Burden of Disease Study 2017. Neuroepidemiology. 2020;54:171–179. doi: 10.1159/000506396. - DOI - PubMed

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