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Review
. 2021 Mar 18;22(6):3093.
doi: 10.3390/ijms22063093.

Liver Transplantation for Colorectal Liver Metastases: Current Management and Future Perspectives

Serban Puia-Negulescu  1 , Fanny Lebossé  2   3 , Jean-Yves Mabrut  1   3 , Xavier Muller  1   3 , Guillaume Rossignol  4 , Teresa Antonini  2 , Domitille Erard  2 , Sylvie Radenne  2   5 , Marielle Guillet  5 , Jean-Christophe Souquet  5 , Kayvan Mohkam  1   3 , Mickael Lesurtel  1   3
Affiliations
Review

Liver Transplantation for Colorectal Liver Metastases: Current Management and Future Perspectives

Serban Puia-Negulescu et al. Int J Mol Sci. .

Abstract

Patients with nonresectable liver metastases from colorectal cancer have few therapeutic options and a dismal prognosis. Although liver transplantation for this indication has historically a poor reputation, recent advances in the field of chemotherapy and immunosuppression have paved the way to revisit the concept. New data have shown promising results that need to be validated in several ongoing clinical trials. Since liver grafts represent a scarce resource, several new tools are being explored to expand the donor pool for this indication. The purpose of this review is to present all current available data and perspectives about liver transplantation for nonresectable liver metastases from colorectal cancer.

Keywords: colorectal cancer; colorectal liver metastases; liver transplantation; organ donation; recurrence.

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Conflict of interest statement

The authors declare no conflict of interest.

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