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. 2021 Mar 18;13(3):987.
doi: 10.3390/nu13030987.

Association between Dietary Patterns and Serum Hepatic Enzyme Levels in Adults with Dyslipidemia and Impaired Fasting Plasma Glucose

Li-Yin Lin  1   2   3 , Chien-Yeh Hsu  4   5 , Hung-Yi Chiou  2   3   6 , Hsiu-An Lee  7   8 , Li-Ming Hsu  9 , Po-Ya Chang  10 , Adi Lukas Kurniawan  11 , Jane C-J Chao  1   5   12
Affiliations

Association between Dietary Patterns and Serum Hepatic Enzyme Levels in Adults with Dyslipidemia and Impaired Fasting Plasma Glucose

Li-Yin Lin et al. Nutrients. .

Abstract

We investigated the association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting glucose in Taiwan. A total of 15,005 subjects (5452 men and 9553 women) aged 35-69 years were selected. Two major dietary patterns were identified by principal component analysis: Western dietary pattern and Mediterranean dietary pattern. Subjects in the highest quartile (Q4) of the Western dietary pattern showed an increased risk of elevated serum alanine aminotransferase (ALT) levels (OR: 1.24, 95% CI: 1.06-1.45, p-trend = 0.01). Fur-thermore, in the highest quartile of the Western dietary pattern, subjects with high waist circum-ference were observed to have a greater risk for developing abnormal serum ALT levels compared to those in the lowest quartile (Q1) (OR: 1.43, 95% CI: 1.04-1.97, p-trend = 0.01). In the highest quartile of the Western dietary pattern, only women were at an increased risk for having abnormal serum ALT levels (OR: 1.28, 95% CI: 1.04-1.59, p-trend = 0.03). By contrast, in the highest quartile of the Mediterranean dietary pattern, only men were at a reduced risk for having abnormal serum gamma-glutamyl transferase (GGT) levels (OR: 0.72, 95% CI: 0.53-0.97, p-trend = 0.048). We report a positive association between the Western dietary pattern and abnormal serum ALT levels.

Keywords: Taiwan; cross-sectional study; dietary patterns; dyslipidemia; factor analysis; impaired fasting plasma glucose; serum hepatic enzyme.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Ahmed Z., Ahmed U., Walayat S., Ren J., Martin D.K., Moole H., Koppe S., Yong S., Dhillon S. Liver function tests in identifying patients with liver disease. Clin. Exp. Gastroenterol. 2018;11:301–307. doi: 10.2147/CEG.S160537. - DOI - PMC - PubMed
    1. Niemela O. Biomarkers in alcoholism. Clin. Chim. Acta. 2007;377:39–49. doi: 10.1016/j.cca.2006.08.035. - DOI - PubMed
    1. Tzima N., Pitsavos C., Panagiotakos D.B., Chrysohoou C., Polychronopoulos E., Skoumas J., Stefanadis C. Adherence to the mediterranean diet moderates the association of aminotransferases with the prevalence of the metabolic syndrome; the ATTICA study. Nutr. Metab. 2009;6:30. doi: 10.1186/1743-7075-6-30. - DOI - PMC - PubMed
    1. Hsu C.S., Kao J.H. Non-alcoholic fatty liver disease: An emerging liver disease in Taiwan. J. Formos. Med. Assoc. 2012;111:527–535. doi: 10.1016/j.jfma.2012.07.002. - DOI - PubMed
    1. Chitturi S., Farrell G.C., George J. Non-alcoholic steatohepatitis in the Asia-Pacific region: Future shock? J. Gastroenterol. Hepatol. 2004;19:368–374. doi: 10.1111/j.1440-1746.2003.03252.x. - DOI - PubMed

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