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. 2021 Mar 18;13(3):987.
doi: 10.3390/nu13030987.

Association between Dietary Patterns and Serum Hepatic Enzyme Levels in Adults with Dyslipidemia and Impaired Fasting Plasma Glucose

Li-Yin Lin  1   2   3 , Chien-Yeh Hsu  4   5 , Hung-Yi Chiou  2   3   6 , Hsiu-An Lee  7   8 , Li-Ming Hsu  9 , Po-Ya Chang  10 , Adi Lukas Kurniawan  11 , Jane C-J Chao  1   5   12
Affiliations

Association between Dietary Patterns and Serum Hepatic Enzyme Levels in Adults with Dyslipidemia and Impaired Fasting Plasma Glucose

Li-Yin Lin et al. Nutrients. .

Abstract

We investigated the association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting glucose in Taiwan. A total of 15,005 subjects (5452 men and 9553 women) aged 35-69 years were selected. Two major dietary patterns were identified by principal component analysis: Western dietary pattern and Mediterranean dietary pattern. Subjects in the highest quartile (Q4) of the Western dietary pattern showed an increased risk of elevated serum alanine aminotransferase (ALT) levels (OR: 1.24, 95% CI: 1.06-1.45, p-trend = 0.01). Fur-thermore, in the highest quartile of the Western dietary pattern, subjects with high waist circum-ference were observed to have a greater risk for developing abnormal serum ALT levels compared to those in the lowest quartile (Q1) (OR: 1.43, 95% CI: 1.04-1.97, p-trend = 0.01). In the highest quartile of the Western dietary pattern, only women were at an increased risk for having abnormal serum ALT levels (OR: 1.28, 95% CI: 1.04-1.59, p-trend = 0.03). By contrast, in the highest quartile of the Mediterranean dietary pattern, only men were at a reduced risk for having abnormal serum gamma-glutamyl transferase (GGT) levels (OR: 0.72, 95% CI: 0.53-0.97, p-trend = 0.048). We report a positive association between the Western dietary pattern and abnormal serum ALT levels.

Keywords: Taiwan; cross-sectional study; dietary patterns; dyslipidemia; factor analysis; impaired fasting plasma glucose; serum hepatic enzyme.

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Conflict of interest statement

The authors declare no conflict of interest.

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