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Review
. 2021 Mar 25;26(7):1843.
doi: 10.3390/molecules26071843.

(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

Marilyn Hagan  1 , Bu' Hussain Hayee  2 , Ana Rodriguez-Mateos  3
Affiliations
Review

(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

Marilyn Hagan et al. Molecules. .

Abstract

(Poly)phenols (PPs) may have a therapeutic benefit in gastrointestinal (GI) disorders, such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). The aim of this review is to summarise the evidence-base in this regard. Observational evidence does not give a clear indication that PP intake has a preventative role for IBD or IBS, while interventional studies suggest these compounds may confer symptomatic and health-related quality of life improvements in known patients. There are inconsistent results for effects on markers of inflammation, but there are promising reports of endoscopic improvement. Work on the effects of PPs on intestinal permeability and oxidative stress is limited and therefore conclusions cannot be formed. Future work on the use of PPs in IBD and IBS will strengthen the understanding of clinical and mechanistic effects.

Keywords: (poly)phenols; Crohn’s disease; inflammatory bowels disease (IBD); irritable bowel syndrome (IBS); ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) flow diagram for identification of relevant included and excluded studies.
See this image and copyright information in PMC

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