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Review
. 2021 Mar 25;19(4):180.
doi: 10.3390/md19040180.

Marine-Derived Macrolides 1990-2020: An Overview of Chemical and Biological Diversity

Hairong Zhang  1 , Jiabin Zou  1 , Xiaoxue Yan  1 , Junlong Chen  1 , Xiujiao Cao  1 , Jialing Wu  1 , Yinghui Liu  1 , Tingting Wang  1
Affiliations
Review

Marine-Derived Macrolides 1990-2020: An Overview of Chemical and Biological Diversity

Hairong Zhang et al. Mar Drugs. .

Abstract

Macrolides are a significant family of natural products with diverse structures and bioactivities. Considerable effort has been made in recent decades to isolate additional macrolides and characterize their chemical and bioactive properties. The majority of macrolides are obtained from marine organisms, including sponges, marine microorganisms and zooplankton, cnidarians, mollusks, red algae, bryozoans, and tunicates. Sponges, fungi and dinoflagellates are the main producers of macrolides. Marine macrolides possess a wide range of bioactive properties including cytotoxic, antibacterial, antifungal, antimitotic, antiviral, and other activities. Cytotoxicity is their most significant property, highlighting that marine macrolides still encompass many potential antitumor drug leads. This extensive review details the chemical and biological diversity of 505 macrolides derived from marine organisms which have been reported from 1990 to 2020.

Keywords: biological diversity; chemical diversity; cytotoxicity; macrolides; marine organisms.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The percentage of macrolides from diverse marine organisms.
Figure 2
Figure 2
All new macrolides by source/year, n = 505.
See this image and copyright information in PMC

References

    1. Woodward R.B. Struktur und biogenese der makrolide. Angew. Chem. 1957;69:50–58. doi: 10.1002/ange.19570690109. - DOI
    1. Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat. Biotechnol. 2007;25:447–453. doi: 10.1038/nbt1297. - DOI - PubMed
    1. Arsic B., Barber J., Čikoš A., Mladenovic M., Stankovic N., Novak P. 16-Membered macrolide antibiotics: A review. Int. J. Antimicrob. Agents. 2018;51:283–298. doi: 10.1016/j.ijantimicag.2017.05.020. - DOI - PubMed
    1. Butler M.S. Natural products to drugs: Natural product-derived compounds in clinical trials. Nat. Prod. Rep. 2008;25:475–516. doi: 10.1039/b514294f. - DOI - PubMed
    1. Lysenkova L.N., Turchin K.F., Korolev A.M., Dezhenkova L.G., Bekker O.B., Shtil A.A., Danilenko V.N., Preobrazhenskaya M.N. Synthesis and cytotoxicity of oligomycin a derivatives modified in the side chain. Bioorgan. Med. Chem. 2013;21:2918–2924. doi: 10.1016/j.bmc.2013.03.081. - DOI - PubMed

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