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Review
. 2021 Mar 31;13(4):588.
doi: 10.3390/v13040588.

In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?

Katja Giersch  1 , Maura Dandri  1   2
Affiliations
Review

In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?

Katja Giersch et al. Viruses. .

Abstract

The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies.

Keywords: HDV persistence; HDV replication; NTCP; chronic viral hepatitis; hepatitis delta; host restriction factors; human liver chimeric mice; infection; innate immunity; mouse model.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
HDV infection and host factors. HDV: hepatitis D virus; HBV: hepatitis B virus; GPC5: glypican 5; NTCP: sodium taurocholate co-transporting polypeptide; EGF(R): epidermal growth factor (receptor); ES(R): estrogen (receptor); CAD: carbamoyl-phosphatesynthetase 2, aspartate transcarbamylase, and dihydroorotase; cccDNA: covalently closed circular DNA; HBsAg: hepatitis B surface antigen.
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