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Review
. 2021 Mar 31;13(7):1616.
doi: 10.3390/cancers13071616.

The Management of Brain Metastases-Systematic Review of Neurosurgical Aspects

Martin A Proescholdt  1   2 , Petra Schödel  1   2 , Christian Doenitz  1   2 , Tobias Pukrop  2   3 , Julius Höhne  1   2 , Nils Ole Schmidt  1   2 , Karl-Michael Schebesch  1   2
Affiliations
Review

The Management of Brain Metastases-Systematic Review of Neurosurgical Aspects

Martin A Proescholdt et al. Cancers (Basel). .

Abstract

The multidisciplinary management of patients with brain metastases (BM) consists of surgical resection, different radiation treatment modalities, cytotoxic chemotherapy, and targeted molecular treatment. This review presents the current state of neurosurgical technology applied to achieve maximal resection with minimal morbidity as a treatment paradigm in patients with BM. In addition, we discuss the contribution of neurosurgical resection on functional outcome, advanced systemic treatment strategies, and enhanced understanding of the tumor biology.

Keywords: brain metastases; fluorescence-guided surgery; infiltration; neuronavigation; surgical resection.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Renal cell cancer metastasis of the right cingulate gyrus, interhemispheric approach. (a): Surgical field under white light, (b): Surgical field under YELLOW 560 nm filter.
Figure 2
Figure 2
(a,b): Examples of circumferential stripping. Adenocarcinoma metastasis in the right temporal lobe, note the resection cavity diameter exceeds the diameter of the contrast-enhanced lesion (pre- and postoperative. MRI, T1, contrast-enhanced).
Figure 3
Figure 3
Lung cancer brain metastases (BM) of the right pre-motor cortex under white light (a), under YELLOW 560 nm illumination (b), and the brain-tumor-interface with CLE (c). The white circle in (b) indicates the point of the CLE image.
See this image and copyright information in PMC

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