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. 1988:258:149-60.

Angiotensin receptor mediated regulation of transport in the rat proximal tubule

Y L Chan  1 , V Chatsudthipong, T Wang
Affiliations
  • PMID: 3380820

Angiotensin receptor mediated regulation of transport in the rat proximal tubule

Y L Chan et al. Prog Clin Biol Res. 1988.

Abstract

The intracellular mechanism of Ang II action, as supported by the present data, may be summarized by the following: Ang II interacts with its receptors, leading to an increase in cytosolic Ca+2 by mobilization of Ca+2 from intracellular pools. This rise in cytosolic Ca+2 initiates the activation of calmodulin-regulated enzymes. This then leads to inhibition of both JV and JHCO3-.

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