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Review
. 2021 Mar 30;18(7):3585.
doi: 10.3390/ijerph18073585.

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Machiko Minatoya  1 , Reiko Kishi  1
Affiliations
Review

A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment

Machiko Minatoya et al. Int J Environ Res Public Health. .

Abstract

Purpose of review: Bisphenol A and phthalate have been found in the environment, as well as in humans. In this narrative review pre- and postnatal bisphenol A and phthalate exposures, their relationship to neurodevelopment, and the behavioral outcomes of children are elucidated, focusing in particular on the recent case-control, cross-sectional, and longitudinal studies. This review also introduces some of the possible mechanisms behind the observed associations between exposures and outcomes.

Recent findings: Although bisphenol A and phthalate exposure have been reported to influence neurobehavioral development in children, there are various kinds of test batteries for child neurodevelopmental assessment at different ages whose findings have been inconsistent among studies. In addition, the timing and number of exposure assessments have varied.

Summary: Overall, this review suggests that prenatal exposure to bisphenol A and phthalates may contribute to neurobehavioral outcomes in children. The evidence is still limited; however, Attention Deficit Hyperactivity Disorder (ADHD) symptoms, especially among boys, constantly suggested association with both prenatal and concurrent exposure to bisphenol A. Although there is limited evidence on the adverse effects of prenatal and postnatal bisphenol A and phthalate exposures provided, pregnant women and young children should be protected from exposure based on a precautionary approach.

Keywords: bisphenol A; developmental disorder; neurodevelopment; phthalate.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Calafat A. Background Paper on BPA Biomonitoring and Biomarker Studies. World Health Organization; Geneva, Switzerland: 2011.
    1. WHO Joint FAO/WHO Expert Meeting to Review Toxicological and Health Aspects of Bisphenol A: Final Report; Proceedings of the Including Report of Stakeholder Meeting on Bisphenol A; Ottawa, ON, Canada. 1–5 November 2010; Geneva, Switzerland: World Health Organization; 2011.
    1. WHO . United Nations Environment Programme. State of the Science of Endocrine Disrupting Chemicals-2012. World Health Organization; Geneva, Switzerland: 2015.
    1. Vandenberg L.N., Hauser R., Marcus M., Olea N., Welshons W.V. Human exposure to bisphenol A (BPA) Reprod. Toxicol. 2007;24:139–177. doi: 10.1016/j.reprotox.2007.07.010. - DOI - PubMed
    1. Koch H.M., Calafat A.M. Human body burdens of chemicals used in plastic manufacture. Philos. Trans. R. Soc. B: Biol. Sci. 2009;364:2063–2078. doi: 10.1098/rstb.2008.0208. - DOI - PMC - PubMed

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