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Review
. 2021 Mar 16;9(3):263.
doi: 10.3390/vaccines9030263.

Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

Valéria L Carvalho  1   2 , Maureen T Long  1
Affiliations
Review

Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

Valéria L Carvalho et al. Vaccines (Basel). .

Abstract

Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.

Keywords: arbovirus; insect-specific virus; vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic description of the development and production of insect-specific virus-based chimeric vaccines against arboviruses.
See this image and copyright information in PMC

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