Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2021 Mar 22;26(6):1777.
doi: 10.3390/molecules26061777.

Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases

Gaetano Isola  1 , Alessandro Polizzi  1 , Vincenzo Ronsivalle  1 , Angela Alibrandi  2 , Giuseppe Palazzo  1 , Antonino Lo Giudice  1
Affiliations
Clinical Trial

Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases

Gaetano Isola et al. Molecules. .

Abstract

Matrix metalloproteinase-9 (MMP-9) has been shown to play a key role in endothelial function and perhaps pivotal in the correlation between periodontal disease and cardiovascular disease (CVD). For the study, the impact of MMP-9 of periodontitis and CVD on serum and saliva concentrations was analyzed. For the study patients with periodontitis (n = 31), CVD (n = 31), periodontitis + CVD (n = 31), and healthy patients (n = 31) were enrolled. Clinical and demographic characteristics as well as serum and salivary MMP-9 were evaluated. MMP-9 concentrations in serum and saliva were statistically elevated in patients with CVD (p < 0.01) and in patients with periodontitis plus CVD (p < 0.001) compared to patients with periodontitis and healthy subjects. Multivariate regression analysis showed that c-reactive protein (hs-CRP) was the only significant predictor for MMP-9 serum (p < 0.001), whereas hs-CRP (p < 0.001) and total cholesterol (p = 0.029) were the statistically significant salivary MMP-9 predictors. This study evidenced that patients with CVD and periodontitis + CVD presented elevated MMP-9 concentrations in serum and saliva compared to patients with periodontitis and healthy subjects. Furthermore, hs-CRP was a negative predictor of serum and salivary MMP-9.

Keywords: cardiovascular disease; clinical trial; matrix metalloproteinases; periodontitis; saliva; serum.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Metalloproteinases-9 (MMP-9) in saliva (B) and serum (A) (median, 25%; 75% percentiles). §§ p < 0.01 differences vs. periodontitis patients. * p < 0.05, ** p < 0.01, and *** p < 0.001 differences vs. healthy controls.
Figure 2
Figure 2
Correlation among MMP-9 concentrations in serum (A) and saliva (B) with hs-CRP.
Figure 3
Figure 3
Study flowchart.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tonetti M.S., Greenwell H., Kornman K.S. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J. Periodontol. 2018;89:S159–S172. doi: 10.1002/JPER.18-0006. - DOI - PubMed
    1. Widén C., Holmer H., Sättlin S., Renvert S., Lernmark Å., Persson G.R. Periodontal conditions, retinopathy, and serum markers in individuals with type 1 diabetes. J. Periodontol. 2020;91:1436–1443. doi: 10.1002/JPER.19-0641. - DOI - PubMed
    1. Polizzi A., Santonocito S., Vaccaro M., Fichera G., Torrisi S., Ronsivalle V., Palazzo G., Sicari F., Indelicato F. Relationship between periodontitis and psychosocial impact in patients with systemic sclerosis: A clinical study. Mediterr. J. Clin. Psychol. 2020;8:2.
    1. Bilgin Çetin M., Önder C., Orhan K., Kumbasar D., Serdar M.A., Ünsal E. Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study. J. Periodontal Res. 2020;55:895–904. doi: 10.1111/jre.12782. - DOI - PubMed
    1. Schmidt J., Strecker P., Kreuz M., Löffler M., Kiess W., Hirsch C., Thiery J., Baber R., Bae Y.J., Kratzsch J., et al. Stress-related hormones in association with periodontal condition in adolescents—results of the epidemiologic LIFE Child study. Clin. Oral Investig. 2018;23:1793–1802. doi: 10.1007/s00784-018-2599-3. - DOI - PubMed

Publication types