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Review
. 2021 Mar 26;22(7):3418.
doi: 10.3390/ijms22073418.

Gastric Cancer: Advances in Carcinogenesis Research and New Therapeutic Strategies

Lornella Seeneevassen  1 , Emilie Bessède  1   2 , Francis Mégraud  1   2 , Philippe Lehours  1   2 , Pierre Dubus  1   3 , Christine Varon  1
Affiliations
Review

Gastric Cancer: Advances in Carcinogenesis Research and New Therapeutic Strategies

Lornella Seeneevassen et al. Int J Mol Sci. .

Abstract

Gastric cancer's bad incidence, prognosis, cellular and molecular heterogeneity amongst others make this disease a major health issue worldwide. Understanding this affliction is a priority for proper patients' management and for the development of efficient therapeutical strategies. This review gives an overview of major scientific advances, made during the past 5-years, to improve the comprehension of gastric adenocarcinoma. A focus was made on the different actors of gastric carcinogenesis, including, Helicobacter pylori cancer stem cells, tumour microenvironment and microbiota. New and recent potential biomarkers were assessed as well as emerging therapeutical strategies involving cancer stem cells targeting as well as immunotherapy. Finally, recent experimental models to study this highly complex disease were discussed, highlighting the importance of gastric cancer understanding in the hard-fought struggle against cancer relapse, metastasis and bad prognosis.

Keywords: EMT; Helicobacter pylori; biomarkers; cancer stem cell; microbiota; microenvironment; stomach cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Gastric adenocarcinoma histological and molecular classifications.
Figure 2
Figure 2
Gastric carcinogenesis: a Helicobacter disease.
Figure 3
Figure 3
Gastric carcinogenesis: a stem cell disease.
Figure 4
Figure 4
Gastric carcinogenesis: a microenvironment disease.
See this image and copyright information in PMC

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