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Comment
. 2021 Apr 2;6(58):eabi7302.
doi: 10.1126/sciimmunol.abi7302.

Brain tumor T cells inhibited by their natural KLR(B1) instinct

Seneca Oxendine  1 , Kevin C O'Connor  1
Affiliations
Comment

Brain tumor T cells inhibited by their natural KLR(B1) instinct

Seneca Oxendine et al. Sci Immunol. .

Abstract

Charting the gene-expression landscape of glioma-infiltrating T cells demonstrates that these T cells can express NK cell receptors, which inhibit the killing of glioma cells.

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  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.
    Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R, Hara T, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC, Gonzalez Castro LN, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O, Wakimoto H, Rozenblatt-Rosen O, Brastianos PK, Liu XS, Jones PS, Cahill DP, Frosch MP, Louis DN, Freeman GJ, Ligon KL, Marson A, Chiocca EA, Reardon DA, Regev A, Suvà ML, Wucherpfennig KW. Mathewson ND, et al. Cell. 2021 Mar 4;184(5):1281-1298.e26. doi: 10.1016/j.cell.2021.01.022. Epub 2021 Feb 15. Cell. 2021. PMID: 33592174 Free PMC article.

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