Atypical is the new norm, for B cells and the rest of us

Affiliations

¹ Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA. Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA. Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. stephanie.eisenbarth@yale.edu.

Comment

Adam Williams et al. Sci Immunol. 2021.

. 2021 Apr 2;6(58):eabi7304.

doi: 10.1126/sciimmunol.abi7304.

¹ Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA. Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA. Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. stephanie.eisenbarth@yale.edu.

Abstract

An unusual form of activated B cells in adults is described, called atypical B cells, both in the steady state and after vaccination.

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans.
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