Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;11(4):810-814.
doi: 10.1158/2159-8290.CD-21-0124.

The Promising Evolution of Targeted Therapeutic Strategies in Cancer

Solange Peters #  1 , Tony Mok #  2 , Antonio Passaro #  3 , Pasi Antero Jänne #  4
Affiliations

The Promising Evolution of Targeted Therapeutic Strategies in Cancer

Solange Peters et al. Cancer Discov. 2021 Apr.

Abstract

The upcoming decade of precision medicine for cancer is moving from the translation of specific genetic findings into clinically relevant improvement to the qualitative analyses of the genomic and immune tumor microenvironment, for an integrated treatment strategy in both metastatic and early disease.

PubMed Disclaimer

References

    1. Hong DS, Fakih MG, Strickler JH, Desai J, Durm GA, Shapiro GI, et al. KRASG12C inhibition with sotorasib in advanced solid tumors. N Eng J Med. 2020;383:1207–17.
    1. Rolfo C, Russo A. HER2 mutations in non–small cell lung cancer: a herculean effort to hit the target. Cancer Discov. 2020;10:643–5.
    1. Diamantis N, Banerji U. Antibody-drug conjugates - an emerging class of cancer treatment. Br J Cancer. 2016;114:362–7.
    1. Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, et al. Trastuzumab deruxtecan in previously treated HER2-positive breast cancer. N Engl J Med. 2020;382:610–21.
    1. Khan S, He Y, Zhang X, Yuan Y, Pu S, Kong Q, et al. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. Oncogene. 2020;39:4909–24.

LinkOut - more resources