Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 May;12(10):1620-1624.
doi: 10.1111/1759-7714.13952. Epub 2021 Apr 3.

Primary pulmonary Hodgkin's lymphoma mimicking rheumatoid arthritis-associated organizing pneumonia: A case report

Kunyan Sun #  1 , Qing Yu #  1 , Jiaxin Zhou  1 , Hong Zhang  1 , Li Gao  2 , Lin Nong  3 , Mangju Wang  4 , Chengli Que  1
Affiliations
Case Reports

Primary pulmonary Hodgkin's lymphoma mimicking rheumatoid arthritis-associated organizing pneumonia: A case report

Kunyan Sun et al. Thorac Cancer. 2021 May.

Abstract

Primary pulmonary Hodgkin's lymphoma (PPHL) is an extremely rare disease. The nonspecific clinical and radiological features render the diagnosis a great challenge. Here, we present a case of PPHL mimicking rheumatoid arthritis-associated organizing pneumonia.

Keywords: Consolidation and nodules; lung biopsy; organizing pneumonia; primary pulmonary Hodgkin's lymphoma; rheumatoid arthritis.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Images of chest CT scans during the disease course. (a) On admission, multiple consolidation and nodules are distributed along with the bronchial vascular bundle. (b) Absorption of the nodules and consolidation after the administration of diprospan. (c) Four months later, new consolidations and nodules reappear (arrow)
FIGURE 2
FIGURE 2
On PET‐CT scan, F‐fluorodeoxyglucose (FDG)‐uptake of lung lesions increase to varying degrees, and the uptake is highest in the right lower lung (arrow), without lymphadenopathy and any other abnormal uptake
FIGURE 3
FIGURE 3
(a) Hematoxylin and eosin (H&E) staining demonstrating large atypical lymphoid cells (H&E, 400×). (b) Immunohistochemistry staining negative for CD20 (400×). (c) Immunohistochemistry staining positive for CD30 (400×). (d) Immunohistochemistry staining positive for PAX5 (400×)
FIGURE 4
FIGURE 4
After chemotherapy, chest CT and PET‐CT show that the nodules and consolidations are completely resolved
See this image and copyright information in PMC

References

    1. Piña‐Oviedo S, Weissferdt A, Kalhor N, Moran CA. Primary pulmonary lymphomas. Adv Anat Pathol. 2015;22(6):355–75. - PubMed
    1. Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N. Hodgkin lymphoma in adults. Deutsches Arzteblatt Int. 2018;115(31–32):535–40. - PMC - PubMed
    1. Cartier Y, Johkoh T, Honda O, Müller NL. Primary pulmonary Hodgkin's disease: CT findings in three patients. Clin Radiol. 1999;54(3):182–4. - PubMed
    1. Parissis H. Forty years literature review of primary lung lymphoma. J Cardiothorac Surg. 2011;6:23. - PMC - PubMed
    1. Schild MH, Wong WW, Valdez R, Leis JF. Primary pulmonary classical Hodgkin lymphoma: a case report. J Surg Oncol. 2014;110(3):341–4. - PubMed

Publication types