8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

Andreas H Groll¹, Dorothea Pana², Fanny Lanternier³, Alessio Mesini⁴, Roland A Ammann⁵, Dina Averbuch⁶, Elio Castagnola⁴, Simone Cesaro⁷, Dan Engelhard⁶, Carolina Garcia-Vidal⁸, Jukka Kanerva⁹, Nicole Ritz¹⁰, Emmanuel Roilides¹¹, Jan Styczynski¹², Adilia Warris¹³, Thomas Lehrnbecher¹⁴; 8th European Conference on Infections in Leukaemia

Affiliations

¹ Infectious Disease Research Program, Center for Bone Marrow Transplantation, and Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany. Electronic address: andreas.groll@ukmuenster.de.
² Department of Medicine, European University of Cyprus, Nicosia, Cyprus.
³ Infectious Diseases Unit, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, Paris, France.
⁴ Infectious Diseases Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
⁵ Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, Bern, Switzerland.
⁶ Department of Pediatrics, Hebrew University Medical Center, Jerusalem, Israel.
⁷ Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
⁸ Department of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; IDIBAPS, University of Barcelona, Barcelona, Spain.
⁹ Division of Hematology-Oncology and Stem Cell Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
¹⁰ Pediatric Infectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
¹¹ Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Health Sciences, and Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹² Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹³ MRC Centre for Medical Mycology, University of Exeter, Exeter, UK; Great Ormond Street Hospital London, London, UK.
¹⁴ Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt, Germany.

PMID: 33811813
DOI: 10.1016/S1470-2045(20)30723-3

Review

8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

Andreas H Groll et al. Lancet Oncol. 2021 Jun.

. 2021 Jun;22(6):e254-e269.

doi: 10.1016/S1470-2045(20)30723-3. Epub 2021 Mar 31.

Authors

Affiliations

¹ Infectious Disease Research Program, Center for Bone Marrow Transplantation, and Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany. Electronic address: andreas.groll@ukmuenster.de.
² Department of Medicine, European University of Cyprus, Nicosia, Cyprus.
³ Infectious Diseases Unit, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, Paris, France.
⁴ Infectious Diseases Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
⁵ Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, Bern, Switzerland.
⁶ Department of Pediatrics, Hebrew University Medical Center, Jerusalem, Israel.
⁷ Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
⁸ Department of Infectious Diseases, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; IDIBAPS, University of Barcelona, Barcelona, Spain.
⁹ Division of Hematology-Oncology and Stem Cell Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
¹⁰ Pediatric Infectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
¹¹ Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Health Sciences, and Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹² Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland.
¹³ MRC Centre for Medical Mycology, University of Exeter, Exeter, UK; Great Ormond Street Hospital London, London, UK.
¹⁴ Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt, Germany.

PMID: 33811813
DOI: 10.1016/S1470-2045(20)30723-3

Abstract

Paediatric patients with cancer and those undergoing allogeneic haematopoietic cell transplantation have an increased susceptibility to invasive fungal diseases. In addition to differences in underlying conditions and comorbidities relative to adults, invasive fungal diseases in infants, children, and adolescents are unique in terms of their epidemiology, the validity of current diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of phase 3 clinical trials to provide data to guide evidence-based interventions. To re-examine the state of knowledge and to further improve invasive fungal disease diagnosis, prevention, and management, the 8th European Conference on Infections in Leukaemia (ECIL-8) reconvened a Paediatric Group to review the literature and to formulate updated recommendations according to the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and European Confederation of Medical Mycology (ECMM) grading system, which are summarised in this Review.

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Conflict of interest statement

Declaration of interests AHG reports research support from Gilead Sciences, Merck Sharp and Dohme, and Pfizer; is a consultant for Amplyx, Astellas, Basilea, F2G, Gilead Sciences, Merck Sharp and Dohme, and Pfizer; and served at the speakers' bureau of Astellas, Basilea, F2G, Gilead Sciences, Merck Sharp and Dohme, and Pfizer. FL served at the speakers' bureau of Gilead Sciences and Basilea. DA reports research support from Merck Sharp and Dohme; was a consultant for Pfizer; and served at the speakers' bureau of GlaxoSmithKline. EC is a consultant for Angelini Pharma and Ferrer. CG-V reports research grants from Gilead Sciences and Merck Sharp and Dohme; and served at the speakers' bureau of Gilead Sciences, Merck Sharp and Dohme, Novartis, Pfizer, Jannsen, and Lilly. JK is a consultant for Bayer. ER reports research grants from Astellas, Gilead Sciences, Merck Sharp and Dohme, and Pfizer; and is a scientific advisor and member of speakers' bureaus for Astellas, Gilead Sciences, Merck Sharp and Dohme, and Pfizer. JS reports scientific grants or serving at the speakers' bureau of Merck Sharp and Dohme, Gilead Sciences, Roche, Pfizer, and Astellas; and participated in the advisory board of Gilead Sciences, Merck Sharp and Dohme, Roche, and Pfizer. AW reports research support from Gilead Sciences; and served at the spearker's bureau of Gilead Sciences. TL reports unrestricted research support from Gilead Sciences; is a consultant for Gilead Sciences, Merck Sharp and Dohme, Pfizer, Astellas, and Roche; and serves at the speakers' bureau of Gilead Sciences, Merck Sharp and Dohme, Astellas, Pfizer, and GlaxoSmithKline. All other authors declare no competing interests.

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8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

Affiliations

8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

Authors

Affiliations

Abstract

Conflict of interest statement

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LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical