doi: 10.1002/1097-0142(197712)40:6<2823::aid-cncr2820400612>3.0.co;2-2.
High dose methotrexate with citrovorum factor in adult resistant lymphoma
- PMID: 338137
- DOI: 10.1002/1097-0142(197712)40:6<2823::aid-cncr2820400612>3.0.co;2-2
Item in Clipboard
High dose methotrexate with citrovorum factor in adult resistant lymphoma
Cancer.
1977 Dec.
Abstract
Seven adult patients with advanced lymphoma, resistant to vincristine, prednisone, alkylating agents and Adriamycin were treated with "high dose" methotrexate and citrovorum factor rescue. Therapy consisted of 4 to 6-hour infusions of methotrexate (5--100 mg/kg) every 1 to 2 weeks with citrovorum rescue initiates 2 to 12 hours after termination of the infusion. Objective responses were obtained in three patients but these were short lived. Mucosal and hematologic toxicity occurred when repeat courses of therapy were administered. The results suggest that high dose methotrexate may be effective therapy in lymphoma, particularlly if citrovorum factor rescue is used early and in adequate dosage.
Similar articles
-
Continuous infusion vincristine and bleomycin with high dose methotrexate for resistant non-Hodgkin's lymphoma.Cancer. 1982 Nov 1;50(9):1690-4. doi: 10.1002/1097-0142(19821101)50:9<1690::aid-cncr2820500906>3.0.co;2-z. Cancer. 1982. PMID: 6180819
-
Combination therapy for diffuse histiocytic lymphoma that includes antimetabolites.Cancer Treat Rep. 1977 Sep;61(6):1109-16. Cancer Treat Rep. 1977. PMID: 332346 Clinical Trial.
-
Chemotherapy of the non-Hodgkin's lymphomas.Cancer. 1978 Aug;42(2 Suppl):932-40. doi: 10.1002/1097-0142(197808)42:2+<932::aid-cncr2820420716>3.0.co;2-2. Cancer. 1978. PMID: 356958 Review. No abstract available.
-
Methotrexate and citrovorum factor rescue in the management of childhood lymphosarcoma and reticulum cell sarcoma (non-Hodgkin's lymphomas): parolonged unmaintained remissions.Cancer. 1976 Sep;38(3):1043-51. doi: 10.1002/1097-0142(197609)38:3<1043::aid-cncr2820380302>3.0.co;2-u. Cancer. 1976. PMID: 782684
-
Proceedings: Malignant lymphoma: treatment with combination chemotherapy.Proc Natl Cancer Conf. 1972;7:379-90. Proc Natl Cancer Conf. 1972. PMID: 4587651 Review. No abstract available.
Cited by
-
Therapy of primary central nervous system lymphoma with pre-irradiation methotrexate, cyclophosphamide, doxorubicin, vincristine, and dexamethasone (MCHOD).J Neurooncol. 1996 Dec;30(3):257-65. doi: 10.1007/BF00177277. J Neurooncol. 1996. PMID: 8943101 Clinical Trial.
-
An indication of possible impending toxicity during moderately high dose methotrexate infusions.Br J Clin Pharmacol. 1978 Dec;6(6):551-2. doi: 10.1111/j.1365-2125.1978.tb00887.x. Br J Clin Pharmacol. 1978. PMID: 569491 Free PMC article. No abstract available.