Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 26:16:825-834.
doi: 10.2147/COPD.S292666. eCollection 2021.

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Yiben Huang #  1 , Jianing Wang #  1   2 , Jiamin Shen #  1   2 , Jiedong Ma  1   2 , Xiaqi Miao  1   2 , Keke Ding  1   2 , Bingqian Jiang  1   2 , Binbin Hu  1   2 , Fangyi Fu  1   2 , Lingzhi Huang  1 , Meiying Cao  3 , Xiaodiao Zhang  1
Affiliations

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Yiben Huang et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Background: We aimed to investigate the association between red cell index (RCI) and the severity of Chronic Obstructive Pulmonary Disease (COPD), and compare predictive value of RCI, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) for the severity of COPD.

Methods: A total of 207 participants were recruited (100 COPD patients and 107 healthy controls). COPD patients were divided into two groups according to the optimal cut-off value of RCI determined by the receiver operating characteristic (ROC) curve. Pearson's correlation test, logistic regression analysis and other tests were performed.

Results: Compared with low RCI group, the forced expiration volume in 1 second (FEV1) and FEV1 in percent of the predicted value (FEV1%) in high RCI group were lower (p = 0.016, p = 0.001). There was a negative correlation between RCI and FEV1% (r = -0.302, p = 0.004), while no correlation between FEV1% and NLR as well as PLR were found. RCI showed higher predictive value than NLR and PLR for predicting Global Initiative for Chronic Obstructive Lung Disease classification (GOLD), with a cut-off value of 1.75 and area under the curve (AUC) of 0.729 (p = 0.001). Multivariate logistic regression analysis proved that RCI was an independent factor for lung function in COPD patients (odds ratio [OR] = 4.27, 95% CI: 1.57-11.63, p = 0.004).

Conclusion: RCI is a novel biomarker that can better assess pulmonary function and severity of COPD than NLR and PLR. Higher RCI is related to deterioration of pulmonary function.

Keywords: COPD; RCI; biomarker; pulmonary function.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests in this work.

Figures

Figure 1
Figure 1
Flow chart showing the literature search and selection. Specific reasons for exclusion of studies are also shown.
Figure 2
Figure 2
Correlations of the RCI, NLR and PLR with FEV1%.
Figure 3
Figure 3
ROC curves of the RCI, NLR, PLR, Lym and RDW of COPD patients, for predicting severe or mild COPD. The area under ROC curve of RCI: 0.729; 95% CI: 0.619–0.839; p = 0.001.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lopez-Campos JL, Tan W, Soriano JB. Global burden of COPD. Respirology. 2016;21(1):14–23. doi:10.1111/resp.12660 - DOI - PubMed
    1. Rabe KF, Watz H. Chronic obstructive pulmonary disease. The Lancet. 2017;389(10082):1931–1940. doi:10.1016/s0140-6736(17)31222-9 - DOI - PubMed
    1. Eisner M, Blanc P, Sidney S, et al. Body composition and functional limitation in COPD. Respir Res. 2007;8:7. doi:10.1186/1465-9921-8-7 - DOI - PMC - PubMed
    1. Andelid K, Bake B, Rak S, Linden A, Rosengren A, Ekberg-Jansson A. Myeloperoxidase as a marker of increasing systemic inflammation in smokers without severe airway symptoms. Respir Med. 2007;101(5):888–895. doi:10.1016/j.rmed.2006.09.023 - DOI - PubMed
    1. Houghton AM, Rzymkiewicz DM, Ji H, et al. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010;16(2):219–223. doi:10.1038/nm.2084 - DOI - PMC - PubMed