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Review
. 2021 Mar 18:12:629636.
doi: 10.3389/fimmu.2021.629636. eCollection 2021.

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

Ciaran Gilbride  1 , Jack Saunders  1 , Hannah Sharpe  1 , Emmanuel Atangana Maze  2 , Georgina Limon  2 , Anna Barbara Ludi  2 , Teresa Lambe  1 , Sandra Belij-Rammerstorfer  1
Affiliations
Review

The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever

Ciaran Gilbride et al. Front Immunol. .

Abstract

Outbreaks that occur as a result of zoonotic spillover from an animal reservoir continue to highlight the importance of studying the disease interface between species. One Health approaches recognise the interdependence of human and animal health and the environmental interplay. Improving the understanding and prevention of zoonotic diseases may be achieved through greater consideration of these relationships, potentially leading to better health outcomes across species. In this review, special emphasis is given on the emerging and outbreak pathogen Crimean-Congo Haemorrhagic Fever virus (CCHFV) that can cause severe disease in humans. We discuss the efforts undertaken to better understand CCHF and the importance of integrating veterinary and human research for this pathogen. Furthermore, we consider the use of closely related nairoviruses to model human disease caused by CCHFV. We discuss intervention approaches with potential application for managing CCHFV spread, and how this concept may benefit both animal and human health.

Keywords: CCHF; Hazara; NHP model; NSDV; One Health; mouse model; vaccines; veterinary vaccines.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Plowright RK, Parrish CR, McCallum H, Hudson PJ, Ko AI, Graham AL, et al. . Pathways to zoonotic spillover. Nat Rev Microbiol (2017) 15:502–10. 10.1038/nrmicro.2017.45 - DOI - PMC - PubMed
    1. Monath TP. Vaccines against diseases transmitted from animals to humans: a one health paradigm. Vaccine (2013) 31:5321–38. 10.1016/j.vaccine.2013.09.029 - DOI - PMC - PubMed
    1. Anderson RM, Fraser C, Ghani AC, Donnelly CA, Riley S, Ferguson NM, et al. . Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic. Philos Trans R Soc Lond B Biol Sci (2004) 359:1091–105. 10.1098/rstb.2004.1490 - DOI - PMC - PubMed
    1. Al-Omari A, Rabaan AA, Salih S, Al-Tawfiq JA, Memish ZA. MERS coronavirus outbreak: Implications for emerging viral infections. Diagn Microbiol Infect Dis (2019) 93:265–85. 10.1016/j.diagmicrobio.2018.10.011 - DOI - PMC - PubMed
    1. Thanh TT, van Doorn HR, de Jong MD. Human H5N1 influenza: Current insight into pathogenesis. Int J Biochem Cell Biol (2008) 40:2671–4. 10.1016/j.biocel.2008.05.019 - DOI - PubMed

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