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. 2021 Feb 18;16(1):150-159.
doi: 10.1515/biol-2021-0019. eCollection 2021.

Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

Yafen Zhuo  1 , Lin Ling  1 , Zhichun Sun  1 , Wensen Huang  2 , Zhenzhen Hong  1 , Yaping Zhang  1 , Xuefeng Peng  1 , Xiaoyu Liu  3 , Weilan Yuan  4 , Wang-Yang Xu  5 , Yi Zhang  1
Affiliations

Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

Yafen Zhuo et al. Open Life Sci. .

Abstract

The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson's correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90-2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.

Keywords: 25(OH)D level; T2DM risk; a prediction model; type 2 diabetes mellitus; urinary iodine concentration; vitamin D.

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Conflict of interest statement

Conflict of interest: The authors state no conflict of interest.

Figures

Figure 1
Figure 1
Pearson’s correlation between clinical factors and T2DM risk.
Figure 2
Figure 2
A prediction model for screening the high-risk T2DM in the population.
Figure A1
Figure A1
Established models for the prediction of T2DM risk. (a) The prediction model without 25(OH)D level. (b) The prediction model without UIC. (c) The prediction model without 25(OH)D level and UIC.
See this image and copyright information in PMC

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