Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jul-Dec;41(2):210-212.
doi: 10.4103/ijstd.IJSTD_69_19. Epub 2020 Nov 11.

An unusual secondary extramammary Paget's disease of vulva

Alvish Noel  1 , Ramesh M Bhat  1 , Sujaya V Rao  2 , Shannon Fernandes  2
Affiliations
Case Reports

An unusual secondary extramammary Paget's disease of vulva

Alvish Noel et al. Indian J Sex Transm Dis AIDS. 2020 Jul-Dec.

Abstract

Extramammary Paget's disease (EMPD) of the vulva is a rare disease that occurs mainly in postmenopausal women. It can be primary or secondary. Prognosis of primary EMPD is good, but when secondary, we need to find the underlying malignancy as the prognosis depends on it. Very few cases of secondary EMPD of the vulva have been reported till now. We hereby report a case of a 65-year-old postmenopausal woman with EMPD secondary to invasive adenocarcinoma with neuroendocrine features in the dermis and she was treated surgically followed by radiotherapy.

Keywords: Extramammary Paget's disease; genital malignancy; vulval carcinoma.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Clinical photograph showing erythematous plaque measuring about 6 cm × 10 cm seen over the left labia majora extending posteriorly to perianal area
Figure 2
Figure 2
Clinical photograph closer view showing lesion surface with gray crusting and nodulation with serosanguinous discharge
Figure 3
Figure 3
Biopsy section showing full-thickness dysplasia of epidermis with Paget's cell in the epidermis (H and E, ×40)
Figure 4
Figure 4
Biopsy section showing Paget's cells which are polygonal-to-oval cells with ground-glass cytoplasm, pleomorphic vesicular nucleus, and prominent nucleoli in the epidermis (H and E, ×100)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Chen K, Liang H, Peng J, Zheng Y. Successful treatment of metastatic extramammary Paget's disease with pemetrexed monotherapy systemically and 5-fluorouracil topically. Indian J Dermatol Venereol Leprol. 2019;85:56–9. - PubMed
    1. Reddy IS, Swain M, Gowrishankar S, Murthy DB. Primary extramammary Paget's disease with extensive skeletal metastases. Indian J Dermatol Venereol Leprol. 2012;78:89–92. - PubMed
    1. Sardesai VR, Agarwal TD, Sakhalkar SP. Extra mammary Paget's disease: A rare case report. Indian J Dermatol. 2015;60:105. - PMC - PubMed
    1. MartIn-Fuentes A, Sánchez-Herreros C, Cuevas-Santos J, De Eusebio-Murillo E. Extramammary Paget disease secondary to a transitional cell carcinoma of the bladder. Indian J Dermatol Venereol Leprol. 2015;81:318–20. - PubMed
    1. Banerjee S, Chatterjee M, Chand K. Extramammary Paget's disease. Indian J Dermatol Venereol Leprol. 2005;71:417–20. - PubMed

Publication types