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Review
. 2020 Jul-Sep;61(3):673-680.
doi: 10.47162/RJME.61.3.05.

Congenital systemic candidiasis: a comprehensive literature review and meta-analysis of 44 cases

Tiberiu Augustin Georgescu  1 , Antonia Carmen Lisievici, Octavian Munteanu, Florentina Ligia Furtunescu, Ovidiu Gabriel Bratu, Costin Berceanu, Roxana Elena Bohîlţea
Affiliations
Review

Congenital systemic candidiasis: a comprehensive literature review and meta-analysis of 44 cases

Tiberiu Augustin Georgescu et al. Rom J Morphol Embryol. 2020 Jul-Sep.

Abstract

Systemic candidiasis is a frequent complication in neonatal units, but congenital systemic candidiasis is an unusual diagnosis, observed in both full-term and preterm infants, with less than 50 cases reported to date. Congenital candidiasis presents with a wide spectrum of symptoms, ranging from diffuse skin eruptions to severe systemic disease, resulting in fetal demise or early neonatal death. Although management guidelines have been published almost two decades ago, due to the rarity of this type of infection, conclusive recommendations are difficult to establish, since they are based on anecdotal experience. In this paper, we present a comprehensive meta-analysis of the current scientific knowledge regarding congenital candidiasis, which spans 54 years and includes a total of 44 cases.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Figure 1
Figure 1
Organ involvement confirmed by culture and/or histopathological examination. GI: Gastrointestinal
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Supplementary concepts