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. 2021 May;53(10):1098-1107.
doi: 10.1111/apt.16353. Epub 2021 Apr 5.

Determinants of IBD-related disability: a cross-sectional survey from the GETAID

Jenny Tannoury  1 , Maria Nachury  2 , Carole Martins  3 , Melanie Serrero  4 , Jerome Filippi  5 , Xavier Roblin  6 , Anne Bourrier  7 , Guillaume Bouguen  8 , Denis Franchimont  9 , Guillaume Savoye  10 , Anthony Buisson  11 , Edouard Louis  12 , Stephane Nancey  13 , Vered Abitbol  7 , Jean-Marie Reimund  14 , Olivier DeWitt  9 , Lucine Vuitton  15 , Nicolas Mathieu  16 , Laurent Peyrin-Biroulet  17 , Cyrielle Gilletta  18 , Matthieu Allez  7 , Stephanie Viennot  19 , Caroline Trang-Poisson  20 , David Laharie  21 , Aurelien Amiot  1 ; GETAID-Patient Experience Study Group
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Free article

Determinants of IBD-related disability: a cross-sectional survey from the GETAID

Jenny Tannoury et al. Aliment Pharmacol Ther. 2021 May.
Free article

Abstract

Background: The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability.

Aims: To identify the predictive factors of disability in a large population of patients with IBD.

Patients and methods: We conducted a cross-sectional survey in 42 tertiary centres in France and Belgium. A self-administered questionnaire was designed to explore patients and their IBD characteristics. IBD-disk is a validated tool to measure disability in patients with IBD. The IBD-disk score was then calculated for each patient. Based on a previous study, an overall IBD-disk score ≥40 was associated with moderate-to-severe disability.

Results: Among the 2011 patients, 1700 were analysed, including 746 (44%) in self-reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate-to-severe disability was significantly increased in patients with BMI >25 kg/m2 (OR = 1.66; 95% CI [1.29-2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79-3.05]) and social worker (OR = 1.54; 95% CI [1.08-2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69-0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53-0.92]), self-reported clinical remission (OR = 0.59; 95% CI [0.46-0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52-0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability.

Conclusion: Determinants of IBD-related disability include IBD-related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.

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References

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