Pituitary neuropeptides and B lymphocyte function
- PMID: 33817820
- DOI: 10.1111/sji.13041
Pituitary neuropeptides and B lymphocyte function
Abstract
This review discusses the accumulated evidence that pro-opiomelanocortin (POMC) gene products as well as other pituitary neuropeptides derived from related genes (Proenkephalin, PENK; Prodynorphin, PDYN, and Pronociceptin, PNOC) can exert direct effects on B lymphocytes to modulate their functions. We also review the available data on receptor systems that might be involved in the transmission of such hormonal signals to B cells.
Keywords: B cells; antibodies/immunoglobulins; human.
© 2021 The Scandinavian Foundation for Immunology.
References
REFERENCES
-
- Decker DA, Grant C, Oh L, Becker P, Young D, Jordan S. Immunomodulatory effects of H.P. Acthar Gel on B cell development in the NZB/W F1 mouse model of systemic lupus erythematosus. Lupus. 2014;23:802-812.
-
- Cusick MF, Libbey JE, Oh L, Jordan S, Fujinami RS. Acthar gel treatment suppresses acute exacerbations in a murine model of relapsing-remitting multiple sclerosis. Autoimmunity. 2014;48:1-9.
-
- Wright D, Fitch R. Repository corticotropin injection (H.P. Acthar Gel) enhances remyelination after cuprizone-induced demyelination. Int J MS Care. 2019;21:61-62.
-
- Olsen NJ, Decker DA, Higgins P, et al. Direct effects of HP Acthar Gel on human B lymphocyte activation in vitro. Arthritis Res Ther. 2015;17:300.
-
- Olsen NJ, Benko AL, McAloose CA, et al. Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro. Clin Immunol. 2019;201:70-78.
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