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Review
. 2021 Apr-Jun;11(2):83-87.
doi: 10.4103/2045-9912.311499.

Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review

Meng-Ling Zhang  1 , Wei Peng  1 , Jian-Qiang Ni  1 , Gang Chen  2
Affiliations
Review

Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review

Meng-Ling Zhang et al. Med Gas Res. 2021 Apr-Jun.

Abstract

Hydrogen sulfide (H2S) is recognized to be a novel mediator after carbon monoxide and nitric oxide in the organism. It can be produced in various mammalian tissues and exert many physiological effects in many systems including the cardiovascular system. A great amount of recent studies have demonstrated that endogenous H2S and exogenous H2S-releasing compounds (such as NaHS, Na2S, and GYY4137) provide protection in many cardiovascular diseases, such as ischemia/reperfusion injury, heart failure, cardiac hypertrophy, and atherosclerosis. In recent years, many mechanisms have been proposed and verified the protective role exhibited by H2S against myocardial ischemia/reperfusion injury, and this review is to demonstrate the protective role of exogenous and endogenous H2S on myocardial ischemia/reperfusion injury.

Keywords: anti-apoptotic; anti-inflammatory; antioxidant; autophagy; hydrogen sulfide; medical gas; mitochondrial preservation; myocardial ischemia/reperfusion injury.

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Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

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